Further, DOP ameliorated the abnormalities of aquaporin-5 (AQP-5) that was supported by in vitro study on A-253 cell line and maintained its function of saliva secretion . Dendrobium officinale in Kew Science Plants of the World online. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Epub 2017 Dec 14. Epub 2012 Nov 29. 2020;43(5):864-872. doi: 10.1248/bpb.b19-01073. DCET-18 (35) also inhibited the migratory behavior and induced the apoptosis of non-small-cell lung cancer cells (human NCI-H460 cells) . Curr Med Sci. Combined with modern medicine, Dendrobium officinale can be used to treat many diseases including Sjögren’s syndrome, gastric ulcer, alcoholic liver injury, chronic obstructive pulmonary disease, diabetes, obesity, rheumatoid arthritis, hypertensive stroke, cataract, weak constitution, or subhealth [2, 20–22]. 2020-05-01 | 0 Comment. Alibaba offers 24 Dendrobium Officinale Kimura Et Migo Suppliers, and Dendrobium Officinale Kimura Et Migo Manufacturers, Distributors, Factories, Companies. 2012R10044-03). Dendrobium Officinale Kimura et Migo Ameliorates Insulin Resistance in Rats with Diabetic Nephropathy. Research showed that two DOP fractions, DOP-1 and DOP-2, promoted splenocyte proliferation, enhanced NK cell-mediated cytotoxicity, and increased the phagocytosis and nitric oxide production of macrophages significantly () . 2013. Sign up here as a reviewer to help fast-track new submissions. Many related patented products are being registered or have been authorized, including Dendrobium officinale ingredients such as antiaging compounds , lactobacillus drink , antiasthenopia eye ointment , immunoenhancement compounds , hypotensive extractive , and hypoglycemic and hypolipidemic compounds . Dendrobium officinale Kimura et Migo: A Review on Its Ethnopharmacology, Phytochemistry, Pharmacology, and Industrialization January 2017 Evidence … Compounds 89–172, isolated from Dendrobium officinale, comprise essential oils. 2019 Aug 28;2019:4127360. doi: 10.1155/2019/4127360. Besides, DOP has manifested anticancer effects in mice with Lewis lung carcinoma (LLC). Research showed that polysaccharides distributing in different parts of Dendrobium officinale varied: middle stem > upper stem > lower stem > roots . In terms of microscopic identification, Dendrobium officinale could be identified by vascular bundle sheath observed under the fluorescence microscopy and the distribution of raphides under normal light microscopy . Dendrobium officinale Kimura et Migo (D. officinale) is a dual-use plant with both botanical medicine and food applications, drawing increasing attentions. Dendrobium, pertaining to the second largest family, Orchidaceae, includes approximately l,400 species worldwide distributed from tropical Asia to Oceania . China > Taiwan, Anhui, Zhejiang, Fujian, Guangxi, Sichuan, Yunnan, Xizang, etc. Therefore, accurate determination of polysaccharide content is of great significance. Finally, industrialization will drive further researches and is conducive to develop deep-processing products, especially the insufficient new drugs, which will also promote the industrialization and form a virtuous circle simultaneously (Figure 3). After acute toxicity test, genetic toxicity test (Ames test, micronucleus test of bone marrow, and sperm shape abnormality test in mice) and 90-day feeding test in rats, the results showed that protocorms of Dendrobium officinale were without toxicity, genetic toxicity and mutagenicity within the scope of the test dose . Research showed that O-acetyl-glucomannan, Dendronan® (Figure 2, A), from Dendrobium officinale  has been isolated and was affirmed immunomodulatory activity in vitro  and in vivo , as well as improvement in colonic health of mice . However, gastric ulcer is a chronic disease, the security of long-term administration of Dendrobium officinale still uncertain. Response of Dendrobium officinale Kimura et Migo, a Prized Medicinal Plant, to Continuous UV-B Irradiation at Different C/N Ratios. From Dendrobium officinale, at least 190 compounds by far were isolated, mainly including polysaccharides, phenanthrenes, bibenzyls, saccharides and glycosides, essential oils, alkaloids, and other compounds (Table 2). In 1987, Dendrobium officinale was on the list of national third-level rare and endangered plants . Et Rchb. As precious medicinal materials, maybe the high price limits the application of tiepishihu. 2017. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. (2) The pharmacological effects of Dendrobium officinale crude extract and polysaccharide were similar, indicating whether other active ingredients were lost during extraction. 2013 Jan;23(1):27-33. doi: 10.3109/15376516.2012.735277. Extraction and quantitative and qualitative analysis are described as follows, and the pharmacological effects of polysaccharides are in Table 3. Dendrobii Officinalis Caulis, the stems of Dendrobium officinale Kimura et Migo, as a tonic herb in Chinese materia medica and health food in folk, has been utilized for the treatment of yin-deficiency diseases for decades. In addition, the development of artificial cultivation of Dendrobium officinale accelerates the promotion of its industrialization in China. In addition, the taxonomy, phylogeny, and breeding of Dendrobium species have made great progress as the advance of molecular markers in the past two decades . Meanwhile, research showed that the DOP group demonstrated higher average scores and an improved average quality of hair growth of C57BL/6J mice (5.0 g/L, the solution was ultra-pure water, each 0.2 mL, smeared for 21 d), compared with the control group. Reference page. Rapid propagation technology has gradually matured, so yield is no longer the bottleneck of Dendrobium officinale development. Erianin significantly inhibited the proliferation of HepG2 and Huh7 (human hepatoma cell lines) in vitro  and also prevented angiogenesis in human hepatoma Be17402 and human melanoma A375 in vivo . Moreover, Dendrobium officinale was used to treat Sjögren’s syndrome (SS) with dry eyes and mouth due to impaired lacrimal and salivary glands . In addition, it could upregulate the expression of ciliary neurotrophic factor (CNTF) mRNA (.05 or .01) . Dendrobium officinale Kimura et Migo (Dendrobium catenatum Lindley), a functional food and medicine herbal, has shown great pharmacological activity on diabetes and hypertension. ),”, X. In addition, compared to the control groups, Dendrobium officinale significantly increased carbon clearance indexes and burden swimming time and reduced the serum lactic acids . In this paper, the ethnopharmacology, phytochemistry, pharmacology, and industrialization of Dendrobium officinale were summarized. Accessed: 2019 April 29. However, these functions were from an earlier investigation and need further research to probe. Dendrobium officinale Kimura et Migo (Dendrobium catenatum Lindley), a prized traditional Chinese Medicine, has been used in China and Southeast Asian countries for centuries. Dendrobium officinale Kimura & Migo leaves were supplied by Senyu Holding Group (Zhejiang, China) which was identified by Herbarium Kunming Institute of Botany Chinese Academy of Sciences. Zhang X, Luo Y, Wei G, Li Y, Huang Y, Huang J, Liu C, Huang R, Liu G, Wei Z, Du S. Evid Based Complement Alternat Med. denneanum picture. Patents and health care products were also improved by the combination of production and research mode. Z. H. He and X. P. He, “One kind of anti-asthenopia Dendrobium candidum,” China Patent CN103961556A, 2014. However, the research of polysaccharide’s ratio of mannose to glucose, the existence of branches, and the substitution position of o-acetyl groups was inconsistent . 2020 Feb;40(1):35-47. doi: 10.1007/s11596-020-2144-x. Recently, increased awareness of the tonic therapeutic effect of Dendrobium officinale has increased the demand and as a consequence the price . Z. H. He and X. P. He, “One kind of immuno-enhancement Dendrobium officinale health products,” China Patent CN103816389A, 2014. There are a variety of methods to enjoy its fresh stems, for example, chewing, juicing, decocting, and making dishes . var. Furthermore, the 15% decoction of Dendrobium officinale was used for mice sperm malformation test, Ames test, and micronucleus test of bone marrow in mice, and all test results were negative. However, TCM physicians use shihu more frequently than tiepishihu. NLM Therefore, the identification of Dendrobium officinale is more precise due to the gene technology, but genetic fingerprints are difficult to evaluate the quality, so the gene technology combining with the physical and chemical identification is necessary. In addition, investigation is needed for better quality control and novel drug or product development. A mixture of D. officinale and American ginseng has been shown to enhance cell-mediated immunity, humoral immunity, and monocyte/macrophage functions in mice. Dendrobium fimbriatum Hook Picture. In this review, from substantial data about Dendrobium officinale, approximately 190 monomer compositions and plenty of pharmacological researches studied in vivo and/or in vitro were summarized. It is apparent that Dendrobium officinale germplasm resources’ separation and purification determine its characters and quality . Generally, there are three methods that can isolate crude Dendrobium officinale polysaccharides (DOP): a solvent method (water extraction by alcohol sedimentation), a biological method (enzyme extraction), and a physical method (ultrasonic extraction and microwave extraction). | Li XW, Huang M, Lo K, Chen WL, He YY, Xu Y, Zheng H, Hu H, Wang J. Molecules. (3) There is no enough systemic data about toxicology of Dendrobium officinale. Advances in the Application of Biomimetic Endometrium Interfaces for Uterine Bioengineering in Female Infertility. Govaerts, R. et al. which belonged to the actual nontoxic category . Find high quality Dendrobium Officinale Kimura Et Migo Suppliers on Alibaba. The hepatoprotective capacity of Dendrobium officinale is always related to its antioxidant ability, especially in acute or chronic alcoholic liver injury. Besides, DOP significantly increased HaCaT cells survival rate and the VEGF mRNA expression levels compared with the control group . Information for analysis of Dendrobium officinale Kimura et Migo was obtained from libraries and Internet scientific databases such as PubMed, Web of Science, Google Scholar, ScienceDirect, Wiley InterScience, Ingenta, Embase, CNKI, and PubChem. Modern pharmacology research has confirmed that Dendrobium officinale and its polysaccharide fraction possess anticancer, hepatoprotective, hypolipidemic, antifatigue, antioxidant, anticonstipation, hypoglycemic, gastric ulcer protective, and antihypertensive effects, immunoenhancement, and so on [2–4]. Its wide modern pharmacological actions in hepatoprotective effect, anticancer effect, hypoglycemic effect, antifatigue effect, gastric ulcer protective effect, and so on were reported. Improving effects on colonic health of mice,”, E. G. Barbosa, L. A. S. Bega, A. Beatriz et al., “A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4,”, Y. Li, C. L. Wang, F. F. Wang et al., “Chemical constituents of, S. Charoenrungruang, P. Chanvorachote, B. Sritularak, and V. Pongrakhananon, “Gigantol, a bibenzyl from Dendrobium draconis, inhibits the migratory behavior of non-small cell lung cancer cells,”, J. Chang, L. J. Xuan, Y. M. Xu, and J. S. Zhang, “Seven new sesquiterpene glycosides from the root bark of Dictamnus dasycarpus,”, J. M. Shao, D. P. Wang, Y. P. Zhang, H. Y. Tang, Y. T. Tan, and W. Li, “Analysis on chemical constituents of volatile oil from stem and leaf of Dendrobium officinale by GC-MS,”, J. A mixture of D. officinale and American ginseng has been shown to enhance cell-mediated immunity, humoral immunity, and monocyte/macrophage functions in mice. What is more, polysaccharides’ pharmacological activities are strongly linked to the composition and content of their monosaccharides . Dendrobium officinale is in the orchid plant family. There are 74 species and 2 variants of genus Dendrobium Sw. in China . Polysaccharides are the main component in dried Dendrobium officinale. HHS (4) How does TCM theory play a role in Dendrobium officinale further in-depth development as theoretical guidance and inspiration source. In addition, Western blot detection and analysis showed that DOE down-regulated the expression of TGF-β, collegan-1, fibronectin, NF-κB, TNF-α and IL-1β. 2020 Feb 28;8:153. doi: 10.3389/fbioe.2020.00153. However, the isolation and identification of one single kind of alkaloid have been rarely reported. 2017, Article ID 7436259, 19 pages, 2017. https://doi.org/10.1155/2017/7436259, 1Zhejiang Chinese Medical University, 548 Binwen Rd., Binjiang District, Hangzhou, China. USA.gov. Wang XT, Gong Y, Zhou B, Yang JJ, Cheng Y, Zhao JG, Qi MY. Biomed Pharmacother. B. Hu, Z. R. Zheng et al., “Preliminary study on the DNA barcoding in Dendrobium officinale germplasm resources,”, X. M. Chen, C. L. Wang, J. S. Yang, and S. X. Guo, “Research progress on chemical composition and chemical analysis of Dendrobium officinale,”, Z. C. Zhang, J. In the last few decades, at least 26 saccharides and glycosides have been found from Dendrobium officinale, (compounds 63–88). Research showed that stroke-prone spontaneously hypertensive (SHR-sp) rats’ living days and survival rates were extended by DOP, and hypotensive effect of DOP was significantly better than the nonpolysaccharide ingredients of Dendrobium officinale . After drying each with different methods, DOP content was arranged as follows: hot air drying > vacuum drying > vacuum freeze drying > natural drying . Hanxiao Tang, Tianwen Zhao, Yunjie Sheng, Ting Zheng, Lingzhu Fu, Yongsheng Zhang, "Dendrobium officinale Kimura et Migo: A Review on Its Ethnopharmacology, Phytochemistry, Pharmacology, and Industrialization", Evidence-Based Complementary and Alternative Medicine, vol. Dendrobium officinale exhibited a significant hypoglycemic effect in adrenaline hyperglycemia mice and streptozotocin-diabetic (STZ-DM) rats . 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